Inhibition of angiotensin converting enzyme with enalapril maleate in infants with congestive heart failure.
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چکیده
منابع مشابه
Angiotensin converting enzyme inhibition in patients with congestive heart failure.
The etiology of afterload elevation in congestive cardiac failure is unclear, but experimental evidence suggests a role for the renin-angiotensin system in maintaining elevated peripheral vascular resistance. The angiotensin converting enzyme inhibitor SQ20,881 was administered to eight patients with congestive cardiac failure (four hypertensives, four normotensives) during or one day after dia...
متن کاملAngiotensin-converting enzyme inhibition restores hepatocyte growth factor production in patients with congestive heart failure.
Endothelium-dependent vasodilation is impaired in patients with congestive heart failure. For vascular endothelium, hepatocyte growth factor (HGF) is one of the most potent and specific growth factors, which acts protectively against endothelial dysfunction. HGF production is downregulated by angiotensin II (Ang II) in vitro. We hypothesized that HGF production is impaired as the result of incr...
متن کاملCombined effects of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism in conscious pigs with congestive heart failure.
OBJECTIVE The goal of this study was to determine if the hemodynamic effects of the combined administration of an angiotensin converting enzyme (ACE) inhibitor and angiotensin II type 1 (AT1) receptor antagonist are greater than those produced by either of these agents administered individually during heart failure. METHODS Ten farm pigs were chronically instrumented with aortic, left atrial ...
متن کاملCombined sympathetic suppression and angiotensin-converting enzyme inhibition in congestive heart failure.
Neurohormonal activation is a pathogenic contributor and prognostic marker in congestive heart failure (CHF). While angiotensin-converting enzyme (ACE) inhibition is now first-line therapy, sympathetic inhibition has only lately been proposed to this aim. Recently, we reported improvement of preload parameters by sympathetic suppression with clonidine. In the present paper we studied the effect...
متن کاملThe effect of progressive aerobic continuous training on angiotensin-1, angiotensin-2 and angiotensin-converting enzyme type 2 in patients with heart failure
Background: Chronic hypertension causes structural and functional changes in the heart, ultimately leading to heart failure (HF), which further increases mortality and morbidit. HF is a complex clinical syndrome caused by various structural or functional abnormalities of the heart that impair the filling capacity of the ventricles. The findings of various trials have shown the association betwe...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1993
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1993.tb04180.x